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CEEHRC / About Epigenetics /
Epigenetic Control of the Epithelial to Mesenchymal Transition in Cancer Metastasis

Abnormal histone modifications affect expression of key epithelial to mesenchymal transition (EMT) marker genes, driving cancer metastasis.

Epigenetic dysregulation enhances cancer cell metabolism

A key characteristic of cancer cells is their ability to adapt their metabolism to their environment, and some of these changes are dependent on epigenetic dysregulation.

Cancer cell
Epigenetic dysregulation ensures tumours are well-fed

In order to grow, proliferate and spread throughout the body, rapidly dividing cancer cells require a constant stream of nutrients and access to the circulatory system.

cancer cell
Targeting cancer cell immortality

A fundamental characteristic shared by cancer cells is the ability to replicate indefinitely—a process that is strongly influenced by epigenetic regulation.

Epigenetics and Highly Mutating Cancer: A Story of Evolution

Aggressive tumours often carry defects in their ability to repair DNA, enabling them to accumulate mutations and adapt to the challenging environment.

Immune cell
Epigenetics and the Hallmarks of Cancer: Evading the immune system

The ability to hide from the immune system is a well-established hallmark of cancer cells.

cell division
Epigenetics and the Hallmarks of Cancer: Evading Apoptosis

Uncontrolled cellular division combined with evasion of apoptosis is a classic hallmark of cancer.

Cell division
Epigenetics and the Hallmarks of Cancer: Insensitivity to antigrowth signals

In healthy tissue, antigrowth signals halt the proliferation of cells. Cells bypassing the them are a step closer to becoming cancerous.