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CEEHRC / About Epigenetics /
Epigenetic dysregulation enhances cancer cell metabolism

A key characteristic of cancer cells is their ability to adapt their metabolism to their environment, and some of these changes are dependent on epigenetic dysregulation.

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Cancer cell
Epigenetic dysregulation ensures tumours are well-fed

In order to grow, proliferate and spread throughout the body, rapidly dividing cancer cells require a constant stream of nutrients and access to the circulatory system.

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cancer cell
Targeting cancer cell immortality

A fundamental characteristic shared by cancer cells is the ability to replicate indefinitely—a process that is strongly influenced by epigenetic regulation.

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Epigenetics and Highly Mutating Cancer: A Story of Evolution

Aggressive tumours often carry defects in their ability to repair DNA, enabling them to accumulate mutations and adapt to the challenging environment.

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Immune cell
Epigenetics and the Hallmarks of Cancer: Evading the immune system

The ability to hide from the immune system is a well-established hallmark of cancer cells.

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cell division
Epigenetics and the Hallmarks of Cancer: Evading Apoptosis

Uncontrolled cellular division combined with evasion of apoptosis is a classic hallmark of cancer.

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Cell division
Epigenetics and the Hallmarks of Cancer: Insensitivity to antigrowth signals

In healthy tissue, antigrowth signals halt the proliferation of cells. Cells bypassing the them are a step closer to becoming cancerous.

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