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CEEHRC / Canadian Publications /

The following is a list of epigenetics and epigenomics peer-reviewed scientific publications with a Canadian First Author or Principal Investigator. Are we missing a Canadian epigenetics publication from this list? Are you a Canadian scientist interested in having your epigenetics study featured on our website, or spotlighted in one of our feature articles? Send the citation to info@epigenomes.ca.

BMC Biology, 2022

Authors:
A. Lorzadeh, C. Hammond, F. Wang, D. J. H. F. Knapp, J. CH. Wong, J. Y. A. Zhu, Q. Cao, A. Heravi-Moussavi, A. Carles, M. Wong, Z. Sharafian, J. Steif, M. Moksa, M. Bilenky, P. M. Lavoie, C. J. Eaves & M. Hirst
Publication Abstract:

Background

Lifelong production of the many types of mature blood cells from less differentiated progenitors is a hierarchically ordered process that spans multiple cell divisions. The nature and timing of the molecular events required to integrate the environmental signals, transcription factor activity, epigenetic modifications, and changes in gene expression involved are thus complex and still poorly understood. To address this gap, we generated comprehensive reference epigenomes of 8 phenotypically defined subsets of normal human cord blood.

Epigenetics & Chromatin, 2022

Authors:
Thomas Dixon-McDougall, Carolyn J Brown
Publication Abstract:

Background

Mammalian dosage compensation is achieved by the inactivation of one X chromosome in XX individuals. In eutheria this process is initiated early in development by the long non-coding RNA XIST. Studies of the initiation of silencing by XIST have focussed on mouse models, so the domains of XIST required to induce silencing in humans, and their relationship with domains required to establish heterochromatin remain to be determined.

Current Opinion in Genetics and Development, 2022

Authors:
GiacomoGrillo, MathieuLupien
Publication Abstract:

The vast array of cell states found across human tissue arises from chromatin variants, which correspond to segments of the genome, known as DNA elements, adopting a different chromatin state over cell state transitions. Oncogenesis stems from alterations to the chromatin states over DNA elements that result in cancer-associated chromatin variants.

, 2022

Authors:
Yi Nian Niu, Eric G Roberts, Danielle Denisko, Michael M Hoffman
Publication Abstract:

Motivation

Bioinformatics software tools operate largely through the use of specialized genomics file formats. Often these formats lack formal specification, making it difficult or impossible for the creators of these tools to robustly test them for correct handling of input and output. This causes problems in interoperability between different tools that, at best, wastes time and frustrates users. At worst, interoperability issues could lead to undetected errors in scientific results.

IUBMB Life, 2022

Authors:
Zahra Sepehri, Archana Banerjee, Frederick S. Vizeacoumar, Andrew Freywald, Franco J. Vizeacoumar, Vernon W. Dolinsky, James R. Davie
Publication Abstract:

The human hepatocyte nuclear factor 1 homeobox A (HNF1A) gene loci express the protein-coding HNF1A transcript and a long non-coding RNA in the anti-sense (HNF1A-AS1) direction. HNF1A-AS1 is expressed in numerous types of cancers and poor clinical outcomes such as higher mortality rates, greater metastatic capacity, and poor prognosis of the disease are the results of this expression.

Gene, 2022

Authors:
Camila López, Mohammad T. Barnon, Tasnim H. Beacon, Gino Nardoccic, James R. Davie
Publication Abstract:

Epigenetic processes are radically altered in cancer cells. The altered epigenetic events may include histone post-translational modifications (PTMs), DNA modifications, and/or alterations in the levels and modifications of chromatin modifying enzymes and chromatin remodelers. With changes in gene programming are changes in the genomic distribution of histone PTMs. Genes that are poised or transcriptionally active have histone H3 trimethylated lysine 4 (H3K4me3) located at the transcription start site and at the 5′ end of the gene.

Frontiers in Molecular Neuroscience, 2021

Authors:
Bonnie Alberry, Benjamin I Laufer, Eric Chater-Diehl, Shiva M Singh
Publication Abstract:

Neurodevelopment in humans is a long, elaborate, and highly coordinated process involving three trimesters of prenatal development followed by decades of postnatal development and maturation. Throughout this period, the brain is highly sensitive and responsive to the external environment, which may provide a range of inputs leading to positive or negative outcomes. Fetal alcohol spectrum disorders (FASD) result from prenatal alcohol exposure (PAE).

STAR Protocols, 2021

Authors:
Ariane Lismer, Romain Lambrot, Christine Lafleur, Vanessa Dumeaux, Sarah Kimmins
Publication Abstract:

In the field of epigenetic inheritance, delineating molecular mechanisms implicated in the transfer of paternal environmental conditions to descendants has been elusive. This protocol details how to track sperm chromatin intergenerationally. We describe mouse model design to probe chromatin states in single mouse sperm and techniques to assess pre-implantation embryo chromatin and gene expression. We place emphasis on how to obtain high-quality and quantifiable data sets in sperm and embryos, as well as highlight the limitations of working with low input.

Molecular and Cellular Biology, 2020

Authors:
Jennifer J Chen, Jean Mbogning, Mark A Hancock, Dorsa Majdpour, Manan Madhok, Hassan Nassour, Juliana C Dallagnol, Viviane Pagé, David Chatenet, Jason C Tanny

Molecular and Cellular Biology, 2020

Authors:
Ryan D Martin, Yalin Sun, Sarah MacKinnon, Luca Cuccia, Viviane Pagé, Terence E Hébert, Jason C Tanny