For those who have not experienced drug addiction, it can be easy to view the disease as a choice—but research shows that epigenetics plays an important role.
Loss of DNA methylation at transposable elements in sperm is associated with decreased sperm function in the offspring.
Abnormal histone modifications affect expression of key epithelial to mesenchymal transition (EMT) marker genes, driving cancer metastasis.
Benjamin Lebeau's research focuses on the oncogenic and epigenetic impact of CTCF mutations or copy number loss in breast cancer.
Dr. Giacomo Grillo is a post doctoral fellow at the University of Toronto where he studies chromatin and transposable element activation in prostate cancer.
Marina Fukano's research focuses on the consequences of metabolic heterogeneity on the progression and drug response of triple-negative breast tumors.
To regenerate damaged muscle, stem cells must be turned into functional muscle cells–a process that requires promoter proximal pausing.
Harnessing new CRISPR epigenome editing toolkits has allowed scientists to begin to understand the function of epigenetic landscapes in living organisms.
Transposable elements are DNA sequences that "jump" through the genome. They're usually silenced through epigenetic processes but still play a vital role.
The regulation of gene expression by transcription enhancers is critical for cellular identity and the observable difference between species.