About Epigenetics

For those who have not experienced drug addiction, it can be easy to view the disease as a choice—but research shows that epigenetics plays an important role.

Loss of DNA methylation at transposable elements in sperm is associated with decreased sperm function in the offspring.

Pairs of the four canonical histones H2A, H2B, H3 and H4 form an octameric core which DNA wraps around to form the nucleosome. These core histones are distributed across chromatin and are specifically expressed during DNA replication (replication-dependent), ensuring proper chromatin folding in daughter cells after cell division. One can imagine histones as bricks of a building that is chromatin, with DNA being the frame. Variations in the material and shape of the bricks confer specific structural properties to the part of the building where they are found.

Unlock the complexities of epigenomic data analysis with this comprehensive guide, from quality control to visualization.

Oncogenic viruses, viruses that drive cancer, use epigenetics to regulate their life cycles and these epigenetic processes can be disrupted in cancer.

Epigenetic editing may outperform gene therapy for complex diseases by controlling, not altering, the genetic code, expanding therapeutic possibilities.

Have you ever wondered why doctors recommend taking folate (also known as folic acid) during pregnancy? Turns out, it's a crucial supplement for the healthy development of growing babies, especially their central nervous system.

Maxime Galloy works on deciphering how the chromatin composition surrounding the DNA damage impact the repair.

Epigenetic plasticity drives castration-resistant prostate cancer (CRPC) to neuroendocrine prostate cancer (NEPC) transition, marked by chromatin remodeling and DNA methylation changes

This article introduces oncohistones and provides a brief overview of commonly studied oncohistone mutations and their involvement in cancer.