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CEEHRC / About Epigenetics /
Mouse Model
Epigenetics and drug addiction: predisposition, chronic use, relapse and treatment

For those who have not experienced drug addiction, it can be easy to view the disease as a choice—but research shows that epigenetics plays an important role.

Mouse Sperm on a Counting Chamber
Epigenetic alteration of the young dark matter in sperm worsens fertility across two successive generations

Loss of DNA methylation at transposable elements in sperm is associated with decreased sperm function in the offspring.

Benjamin Lebeau
Scientist Spotlight: Benjamin Lebeau, McGill University

Benjamin Lebeau's research focuses on the oncogenic and epigenetic impact of CTCF mutations or copy number loss in breast cancer.

Giacomo Grillo
Scientist Spotlight: Dr. Giacomo Grillo, University of Toronto

Dr. Giacomo Grillo is a post doctoral fellow at the University of Toronto where he studies chromatin and transposable element activation in prostate cancer.

cancers
Scientist Spotlight: Marina Fukano, University of Montreal & McGill University

Marina Fukano's research focuses on the consequences of metabolic heterogeneity on the progression and drug response of triple-negative breast tumors.

NELF
Muscle Regenerative Potential Is Ensured Epigenetically Through Promoter Proximal Pausing

To regenerate damaged muscle, stem cells must be turned into functional muscle cells–a process that requires promoter proximal pausing.

CRISPR
Dissecting the epigenome using CRISPR-based engineering technologies

Harnessing new CRISPR epigenome editing toolkits has allowed scientists to begin to understand the function of epigenetic landscapes in living organisms.

corn
Transposable Elements, Epigenetics and Evolution

Transposable elements are DNA sequences that "jump" through the genome. They're usually silenced through epigenetic processes but still play a vital role.

gene-enhancer figure
A Symphony of Speciation

The regulation of gene expression by transcription enhancers is critical for cellular identity and the observable difference between species.

Minggao Liang
Scientist Spotlight: Minggao Liang, University of Toronto

Dr. Minggao Liang's research is focused on elucidating the cis-regulatory consequences of genetic variation in the context of evolution and human disease. Learn more about Minggao.