About Epigenetics

Pairs of the four canonical histones H2A, H2B, H3 and H4 form an octameric core which DNA wraps around to form the nucleosome. These core histones are distributed across chromatin and are specifically expressed during DNA replication (replication-dependent), ensuring proper chromatin folding in daughter cells after cell division. One can imagine histones as bricks of a building that is chromatin, with DNA being the frame. Variations in the material and shape of the bricks confer specific structural properties to the part of the building where they are found.

Unlock the complexities of epigenomic data analysis with this comprehensive guide, from quality control to visualization.

Epigenetic editing may outperform gene therapy for complex diseases by controlling, not altering, the genetic code, expanding therapeutic possibilities.

This article introduces oncohistones and provides a brief overview of commonly studied oncohistone mutations and their involvement in cancer.

The epigenetic inactivation of the X chromosome during embryonic development drives major biological processes – for us and for our favorite pets.

Harnessing new CRISPR epigenome editing toolkits has allowed scientists to begin to understand the function of epigenetic landscapes in living organisms.

Transposable elements are DNA sequences that "jump" through the genome. They're usually silenced through epigenetic processes but still play a vital role.

Over the last decades, there has been much debate regarding chromatin state of matter. Up until recently, chromatin was believed to be liquid.

Epigenetics is a rapidly growing field of scientific inquiry. It explains how our bodies have just one genetic code, but ~200 different cell types.