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Voici une liste de publications scientifiques évaluées par les pairs sur l'épigénétique et l'épigénomique dont le premier auteur ou le chercheur principal est canadien. Manque-t-il une publication canadienne sur l'épigénétique dans cette liste ? Vous êtes un scientifique canadien et vous aimeriez que vos travaux sur l'épigénétique soient présentés sur notre site web ou mis en valeur dans un article de fond? Envoyez la citation à info@epigenomes.ca.

, 2022

Authors:
Yi Nian Niu, Eric G Roberts, Danielle Denisko, Michael M Hoffman
Publication Abstract:

Motivation

Bioinformatics software tools operate largely through the use of specialized genomics file formats. Often these formats lack formal specification, making it difficult or impossible for the creators of these tools to robustly test them for correct handling of input and output. This causes problems in interoperability between different tools that, at best, wastes time and frustrates users. At worst, interoperability issues could lead to undetected errors in scientific results.

IUBMB Life, 2022

Authors:
Zahra Sepehri, Archana Banerjee, Frederick S. Vizeacoumar, Andrew Freywald, Franco J. Vizeacoumar, Vernon W. Dolinsky, James R. Davie
Publication Abstract:

The human hepatocyte nuclear factor 1 homeobox A (HNF1A) gene loci express the protein-coding HNF1A transcript and a long non-coding RNA in the anti-sense (HNF1A-AS1) direction. HNF1A-AS1 is expressed in numerous types of cancers and poor clinical outcomes such as higher mortality rates, greater metastatic capacity, and poor prognosis of the disease are the results of this expression.

Gene, 2022

Authors:
Camila López, Mohammad T. Barnon, Tasnim H. Beacon, Gino Nardoccic, James R. Davie
Publication Abstract:

Epigenetic processes are radically altered in cancer cells. The altered epigenetic events may include histone post-translational modifications (PTMs), DNA modifications, and/or alterations in the levels and modifications of chromatin modifying enzymes and chromatin remodelers. With changes in gene programming are changes in the genomic distribution of histone PTMs. Genes that are poised or transcriptionally active have histone H3 trimethylated lysine 4 (H3K4me3) located at the transcription start site and at the 5′ end of the gene.

Frontiers in Molecular Neuroscience, 2021

Authors:
Bonnie Alberry, Benjamin I Laufer, Eric Chater-Diehl, Shiva M Singh
Publication Abstract:

Neurodevelopment in humans is a long, elaborate, and highly coordinated process involving three trimesters of prenatal development followed by decades of postnatal development and maturation. Throughout this period, the brain is highly sensitive and responsive to the external environment, which may provide a range of inputs leading to positive or negative outcomes. Fetal alcohol spectrum disorders (FASD) result from prenatal alcohol exposure (PAE).

STAR Protocols, 2021

Authors:
Ariane Lismer, Romain Lambrot, Christine Lafleur, Vanessa Dumeaux, Sarah Kimmins
Publication Abstract:

In the field of epigenetic inheritance, delineating molecular mechanisms implicated in the transfer of paternal environmental conditions to descendants has been elusive. This protocol details how to track sperm chromatin intergenerationally. We describe mouse model design to probe chromatin states in single mouse sperm and techniques to assess pre-implantation embryo chromatin and gene expression. We place emphasis on how to obtain high-quality and quantifiable data sets in sperm and embryos, as well as highlight the limitations of working with low input.

Molecular and Cellular Biology, 2020

Authors:
Jennifer J Chen, Jean Mbogning, Mark A Hancock, Dorsa Majdpour, Manan Madhok, Hassan Nassour, Juliana C Dallagnol, Viviane Pagé, David Chatenet, Jason C Tanny

Molecular and Cellular Biology, 2020

Authors:
Ryan D Martin, Yalin Sun, Sarah MacKinnon, Luca Cuccia, Viviane Pagé, Terence E Hébert, Jason C Tanny

Dev Cell, 2021

Authors:
Ariane Lismer, Vanessa Dumeaux, Christine Lafleur, Romain Lambrot, Julie Brind'Amour, Matthew C Lorincz, Sarah Kimmins

Dev Cell, 2021

Authors:
Daniel C L Robinson, Morten Ritso, Geoffrey M Nelson, Zeinab Mokhtari, Kiran Nakka, Hina Bandukwala, Seth R Goldman, Peter J Park, Rémi Mounier, Bénédicte Chazaud, Marjorie Brand, Michael A Rudnicki, Karen Adelman, F Jeffrey Dilworth

Biochim Biophys Acta Mol Basis Dis, 2020

Authors:
Stephens E, Roy M, Bisson M, Nguyen HD, Scott MS, Boire G, Bouchard L, Roux S.