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CEEHRC / About Epigenetics /
packaging of DNA into chromatin
Chromatin State of Matter Matters: Is It Liquid or Solid?

Over the last decades, there has been much debate regarding chromatin state of matter. Up until recently, chromatin was believed to be liquid.

a graphic of the brain with a chromatin overlay
Neurodevelopment has epigenetics on the brain

The brain is a remarkable organ and one of the most complex to assemble. DNA methylation mediates differentiation and regulation.

elderly hand and baby feet
Intergenerational versus transgenerational epigenetic inheritance: the parental environment

The parental environment can influence the health of subsequent generations through epigenetic inheritance.

ultrasound of pregnant woman's stomach
Lifestyle Choices Influence Reproductive Health Through Epigenetics

The reproductive system’s developmental and functional processes strongly rely on dynamic, yet faithful, epigenetic mechanisms from early development to adulthood. The pre-conception health of men and women, along with the in utero environment, have a direct impact on epigenetic modifications in sperm and oocytes (eggs). Therefore, lifestyle choices are key to safeguarding your health, fertility and the health of future children.

Epigenetic dysregulation enhances cancer cell metabolism

A key characteristic of cancer cells is their ability to adapt their metabolism to their environment, and some of these changes are dependent on epigenetic dysregulation.

Cancer cell
Epigenetic dysregulation ensures tumours are well-fed

In order to grow, proliferate and spread throughout the body, rapidly dividing cancer cells require a constant stream of nutrients and access to the circulatory system.

cancer cell
Targeting cancer cell immortality

A fundamental characteristic shared by cancer cells is the ability to replicate indefinitely—a process that is strongly influenced by epigenetic regulation.

Epigenetics and Highly Mutating Cancer: A Story of Evolution

Aggressive tumours often carry defects in their ability to repair DNA, enabling them to accumulate mutations and adapt to the challenging environment.

Immune cell
Epigenetics and the Hallmarks of Cancer: Evading the immune system

The ability to hide from the immune system is a well-established hallmark of cancer cells.

cell division
Epigenetics and the Hallmarks of Cancer: Evading Apoptosis

Uncontrolled cellular division combined with evasion of apoptosis is a classic hallmark of cancer.